QuickView for interleukin 18;jsessionid=C47B1A434373F56C86128178CA0EF9EF;jsessionid=03053B3204E1EA7E21775C94B1429FF8 (gene)
- Gene Symbol:
- Il18
Mus musculus - Full name:
- interleukin 18
- Synonyms:
- Igif, Il-18, interleukin-18, IFN-gamma-inducing factor, IL-1 gamma, interferon gamma-inducing factor, interleukin-1 gamma
- Genomic Location:
- Chr 9: 50373473-50389942
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
| Transcripts Names |
|---|
| NM_008360 |
| XM_006510024 |
| XM_006510026 |
| NM_001357222 |
| XM_017313137 |
| NM_001357221 |
| XM_006510028 |
| XM_006510027 |
GO Molecular Function
interleukin-18 receptor binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity
GO Biological Process
positive regulation of immune response | positive regulation of smooth muscle cell proliferation | regulation of T cell mediated immunity | negative regulation of phosphorylation | adaptive immune response | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | negative regulation of immune system process | detection of stimulus | response to cytokine | neutrophil activation | response to lipopolysaccharide | intracellular signal transduction | positive regulation of apoptotic process | regulation of localization | positive regulation of collagen metabolic process | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | regulation of immune system process | response to hormone | negative regulation of cellular process | positive regulation of developmental process | positive regulation of lymphocyte activation | regulation of T cell differentiation | detection of mechanical stimulus involved in sensory perception | defense response | negative regulation of protein phosphorylation | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | sensory perception of mechanical stimulus | blood vessel morphogenesis | positive regulation of T cell differentiation | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | extrinsic apoptotic signaling pathway | positive regulation of immune effector process | positive regulation of reactive oxygen species metabolic process | positive regulation of adaptive immune response | T-helper 1 type immune response | positive regulation of protein kinase activity | negative regulation of apoptotic process | response to hypoxia | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | positive regulation of natural killer cell proliferation | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cell differentiation | positive regulation of interleukin-8 production | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | positive regulation of activated T cell proliferation | regulation of blood vessel remodeling | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | regulation of type 2 immune response | positive regulation of cellular protein metabolic process | regulation of natural killer cell activation | positive regulation of T cell cytokine production | cellular response to organonitrogen compound | MAPK cascade | T cell cytokine production | positive regulation of tumor necrosis factor production | positive regulation of interleukin-17 production | response to stimulus | vasculature development | positive regulation of NIK/NF-kappaB signaling | positive regulation of cold-induced thermogenesis | regulation of macrophage derived foam cell differentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of myeloid cell apoptotic process | signal transduction by protein phosphorylation | regulation of CD4-positive, alpha-beta T cell activation | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | regulation of germ cell proliferation | positive regulation of JAK-STAT cascade | positive regulation of lymphocyte proliferation | regulation of cell proliferation | sterol homeostasis | tube morphogenesis | response to peptide | negative regulation of neutrophil apoptotic process | positive regulation of cell-cell adhesion | cholesterol homeostasis | regulation of smooth muscle cell migration | programmed cell death | positive regulation of cell activation | positive regulation of natural killer cell activation | positive regulation of superoxide anion generation | cardiovascular system development | response to molecule of bacterial origin | positive regulation of T cell activation | extrinsic apoptotic signaling pathway via death domain receptors | cellular response to organic cyclic compound | blood circulation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | regulation of cell adhesion | macromolecule modification | activation of protein kinase activity | molecular function regulator | regulation of lymphocyte differentiation | blood vessel development | interleukin-18-mediated signaling pathway | regulation of nucleic acid-templated transcription | detection of abiotic stimulus | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | positive regulation of mononuclear cell proliferation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | regulation of superoxide metabolic process | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | positive regulation of T-helper 1 cell cytokine production | multicellular organism development | positive regulation of lymphocyte differentiation | cellular response to peptide hormone stimulus | phosphorus metabolic process | regulation of collagen biosynthetic process | positive regulation of smooth muscle cell migration | leukocyte mediated immunity | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of phosphorylation | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | detection of mechanical stimulus involved in sensory perception of pain | positive regulation of alpha-beta T cell differentiation | regulation of activated T cell proliferation | regulation of gene expression | cell killing | response to lipid | nervous system process | cellular response to peptide | interferon-gamma biosynthetic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | sleep | cellular response to interleukin-18 | CD4-positive, alpha-beta T cell cytokine production | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of STAT cascade | regulation of vascular permeability | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of T-helper 2 cell differentiation | regulation of cellular component movement | regulation of transcription by RNA polymerase II | negative regulation of myoblast differentiation | positive regulation of cell differentiation | activation of protein kinase B activity | regulation of T cell cytokine production | positive regulation of blood vessel remodeling | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | positive regulation of NK T cell activation | sensory perception of pain | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | angiogenesis | phosphorylation | triglyceride homeostasis | positive regulation of neuron death | interleukin-6 production | positive regulation of chemokine production | cytokine production involved in immune response | protein phosphorylation | regulation of tumor necrosis factor production | phosphate-containing compound metabolic process | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of natural killer cell proliferation | positive regulation of NK T cell proliferation | regulation of neuron apoptotic process | positive regulation of tyrosine phosphorylation of STAT protein | regulation of alpha-beta T cell differentiation | positive regulation of macrophage derived foam cell differentiation | inflammatory response | T cell mediated immunity | regulation of cytokine production involved in immune response | regulation of collagen metabolic process | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | positive regulation of germ cell proliferation | regulation of locomotion | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | apoptotic signaling pathway | lymphocyte activation | positive regulation of molecular function | cytokine production | regulation of signaling receptor activity | receptor regulator activity | protein metabolic process | positive regulation of type 2 immune response | positive regulation of T-helper cell differentiation | positive regulation of protein modification process | response to organic substance | regulation of hemopoiesis | regulation of JAK-STAT cascade | regulation of kinase activity | response to mechanical stimulus | detection of stimulus involved in sensory perception | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | positive regulation of vascular permeability | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | regulation of myoblast differentiation | positive regulation of cytokine production involved in immune response | regulation of tissue remodeling | chemical homeostasis | positive regulation of cell death | regulation of myeloid cell apoptotic process | receptor ligand activity | immune response | leukocyte mediated cytotoxicity | cytokine activity | organic substance metabolic process | positive regulation of T-helper 1 type immune response | cell death | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | detection of mechanical stimulus | response to interleukin-18 | positive regulation of cytokine production | cell activation | positive regulation of T cell mediated immunity | natural killer cell mediated immunity | anatomical structure formation involved in morphogenesis | regulation of T-helper cell differentiation | negative regulation of protein metabolic process | sensory perception | regulation of cell communication | natural killer cell activation | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | negative regulation of peptidyl-tyrosine phosphorylation | regulation of T cell proliferation | positive regulation of CD4-positive, alpha-beta T cell differentiation | negative regulation of leukocyte apoptotic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | response to biotic stimulus | positive regulation of tissue remodeling | regulation of developmental process | cytokine biosynthetic process | interleukin-13 biosynthetic process | positive regulation of male germ cell proliferation | developmental process | positive regulation of alpha-beta T cell activation | natural killer cell mediated cytotoxicity | cellular protein modification process | acylglycerol homeostasis | regulation of chemokine production | tube development | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | regulation of cell-cell adhesion | regulation of superoxide anion generation | innate immune response | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | cytokine metabolic process | regulation of male germ cell proliferation | interleukin-13 production | T-helper 1 cell cytokine production | positive regulation of metabolic process | regulation of interferon-gamma production | immune system process | positive regulation of collagen biosynthetic process | cellular metabolic process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | positive regulation of CD4-positive, alpha-beta T cell activation | negative regulation of cell death | circulatory system development | positive regulation of leukocyte cell-cell adhesion | lipid homeostasis | negative regulation of cell differentiation | response to other organism | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | interferon-gamma production | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
apical plasma membrane | cell | cytoplasm | apical part of cell | plasma membrane | extracellular region | extracellular space | cell periphery | intracellular | membrane
